{"id":4434,"date":"2025-04-23T13:46:12","date_gmt":"2025-04-23T13:46:12","guid":{"rendered":"https:\/\/villamedicina.hu\/?post_type=szolgaltatas&#038;p=4434"},"modified":"2025-06-02T10:18:03","modified_gmt":"2025-06-02T10:18:03","slug":"oroklodo-mell-es-petefeszek-rakhajlam-szures-brca","status":"publish","type":"szolgaltatas","link":"https:\/\/villamedicina.hu\/en\/szolgaltatas\/oroklodo-mell-es-petefeszek-rakhajlam-szures-brca\/","title":{"rendered":"Hereditary breast and ovarian cancer screening \u2013 BRCA"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"4434\" class=\"elementor elementor-4434\" data-elementor-post-type=\"szolgaltatas\">\n\t\t\t\t<div class=\"elementor-element elementor-element-02f1b91 e-flex e-con-boxed e-con e-parent\" data-id=\"02f1b91\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-1eddbf0 e-con-full e-flex e-con e-child\" data-id=\"1eddbf0\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-b67dc06 e-con-full e-flex e-con e-child\" data-id=\"b67dc06\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-164ea17 e-flex e-con-boxed e-con e-child\" data-id=\"164ea17\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6ba9fb9 elementor-widget elementor-widget-image\" data-id=\"6ba9fb9\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 15-07-2024 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1920\" height=\"1277\" src=\"https:\/\/villamedicina.hu\/wp-content\/uploads\/2025\/04\/BRCA_VM-scaled.jpg\" class=\"attachment-full size-full wp-image-4448\" alt=\"\" srcset=\"https:\/\/villamedicina.hu\/wp-content\/uploads\/2025\/04\/BRCA_VM-scaled.jpg 1920w, https:\/\/villamedicina.hu\/wp-content\/uploads\/2025\/04\/BRCA_VM-300x199.jpg 300w, https:\/\/villamedicina.hu\/wp-content\/uploads\/2025\/04\/BRCA_VM-1024x681.jpg 1024w, https:\/\/villamedicina.hu\/wp-content\/uploads\/2025\/04\/BRCA_VM-768x511.jpg 768w, https:\/\/villamedicina.hu\/wp-content\/uploads\/2025\/04\/BRCA_VM-1536x1021.jpg 1536w, https:\/\/villamedicina.hu\/wp-content\/uploads\/2025\/04\/BRCA_VM-2048x1362.jpg 2048w, https:\/\/villamedicina.hu\/wp-content\/uploads\/2025\/04\/BRCA_VM-18x12.jpg 18w\" sizes=\"(max-width: 1920px) 100vw, 1920px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cd6cdb6 e-flex e-con-boxed e-con e-child\" data-id=\"cd6cdb6\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c0fef4c elementor-widget elementor-widget-heading\" data-id=\"c0fef4c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 15-07-2024 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h1 class=\"elementor-heading-title elementor-size-default\">Hereditary breast and ovarian cancer screening \u2013 BRCA<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-66945ad elementor-widget elementor-widget-text-editor\" data-id=\"66945ad\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 15-07-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\tGenetics no longer just tells us about our past \u2013 it can also shape our future health. We are increasingly learning that certain inherited gene mutations can significantly increase the risk of developing cancer. \t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-30aecf2 elementor-mobile-align-center elementor-align-left elementor-widget elementor-widget-global elementor-global-2449 elementor-widget-button\" data-id=\"30aecf2\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-md\" href=\"https:\/\/villamedicina.salonic.hu\/showServices\/?placeId=3176&#038;specId=58906\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">APPOINTMENT<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a554184 e-flex e-con-boxed e-con e-parent\" data-id=\"a554184\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4bf2dc5 elementor-widget elementor-widget-text-editor\" data-id=\"4bf2dc5\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>In Hungary, approximately 8,000 women and 200 men are diagnosed with breast cancer each year, and every tenth Hungarian woman will encounter this disease in her lifetime. 10-15% of breast and ovarian cancer is hereditary, often with a familial clustering. If there has been no such disease in the family, but the patient develops the cancer before the age of 50, there is a higher chance of a hereditary BRCA mutation.<\/p><p>The BRCA1 and BRCA2 genes are responsible for correcting errors in the genetic material of cells. If an inherited mutation in these genes is detected in someone, their body may be more likely to develop certain types of cancer \u2013 especially breast and ovarian cancer. Mutations in the different cancer-prone genes can increase the risk of breast cancer as well as other cancers (e.g. ovarian cancer, prostate cancer).\u00a0<\/p><p>BRCA testing allows us to identify these hereditary risks. This can be especially important if there has been a family history of cancer for several generations or if the diagnosis was made at a relatively young age.<\/p><h5>Genes analyzed in the gene panel test:<\/h5><p>ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, DICER1, EPCAM, FANCM, MLH1, MRE11A, MSH2, MSH6, NBN, NF1, PALB2, PMS2, PTEN, RAD51C, RAD51D, SMARCA4, STK11, TP53, XRCC2<\/p><p>It is important to know that although we call it a BRCA test, mutations in the BRCA1 and BRCA2 genes only cause about 25% of hereditary cases, so it is reasonable to also test for other breast cancer susceptibility genes known to medical science. This 25-gene panel aims to screen all possible genes at once, so that the mutation can be identified with a high probability, if present, and ruled out if not present in the person being tested.<\/p><h4>What is worth knowing about BRCA gene testing?<\/h4><p style=\"text-align: justify; text-justify: inter-ideograph; margin: 12.0pt 0cm 12.0pt 0cm;\"><span style=\"white-space: pre-wrap;\"><span style=\"font-family: Montserrat; color: #333333;\">The BRCA1 and BRCA2 genes play a key role in repairing DNA damage in cells. If these genes have an inherited defect, called a mutation, the risk of developing certain cancers can be significantly increased in affected individuals. In particular, in the case of breast and ovarian cancer, it is known that damage to the BRCA genes dramatically increases the risk of the disease.<\/span><\/span><\/p><h4>Why is BRCA testing important?<\/h4><p>BRCA testing is a modern genetic screening that helps to reveal whether a given person has an inherited predisposition to developing the aforementioned types of tumors. So, whether they need to pay more attention than average to cancer screening and prevention.<\/p><p>In the case of an existing disease, we obtain extremely useful results by performing the full 25-gene test:<\/p><ul><li>\u00a0On the one hand, the surgeon can plan the operation more accurately if she has this information;(n\u0151nem\u0171)<\/li><li>on the other hand, in the case of a BRCA mutation, special targeted therapy drugs (PARP inhibitors) may be considered, which will assist the oncologist's work;<\/li><li>Thirdly, it becomes clear whether there is a hereditary predisposing mutation in the family (e.g. in children, siblings), which the geneticist can help you navigate.<\/li><\/ul><p>\u00a0<\/p><h4>What does a positive or negative result mean?<\/h4><ul><li>Positive result: The patient has inherited a mutation, which increases her risk of developing breast or ovarian cancer. This information allows for closer monitoring, targeted screening, and even preventive medical interventions (e.g., risk-reducing surgeries).<\/li><li>Negative result: No known cancer-causing mutation can be detected, which significantly reduces the individual risk, however, it is important to keep in mind that the majority of tumors are not hereditary, so regular screening tests and a healthy lifestyle remain important.<\/li><li>Variant of unknown significance: In this case, a rare gene variant is identified, the effects of which are not yet sufficiently scientifically known to determine whether they are benign or malignant. In such cases, our genetic doctors will help you navigate the next steps.<\/li><\/ul><div>\u00a0<\/div><h4>Who is the test recommended for?<\/h4>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6ab7bc3 elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"6ab7bc3\" data-element_type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<link rel=\"stylesheet\" href=\"https:\/\/villamedicina.hu\/wp-content\/plugins\/elementor\/assets\/css\/widget-icon-list.min.css\">\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-heart\" viewbox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M462.3 62.6C407.5 15.9 326 24.3 275.7 76.2L256 96.5l-19.7-20.3C186.1 24.3 104.5 15.9 49.7 62.6c-62.8 53.6-66.1 149.8-9.9 207.9l193.5 199.8c12.5 12.9 32.8 12.9 45.3 0l193.5-199.8c56.3-58.1 53-154.3-9.8-207.9z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Anyone with a family history of breast, ovarian, prostate, or pancreatic cancer<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-heart\" viewbox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M462.3 62.6C407.5 15.9 326 24.3 275.7 76.2L256 96.5l-19.7-20.3C186.1 24.3 104.5 15.9 49.7 62.6c-62.8 53.6-66.1 149.8-9.9 207.9l193.5 199.8c12.5 12.9 32.8 12.9 45.3 0l193.5-199.8c56.3-58.1 53-154.3-9.8-207.9z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Anyone who has already been diagnosed with such a tumor, especially before the age of 50<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-heart\" viewbox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M462.3 62.6C407.5 15.9 326 24.3 275.7 76.2L256 96.5l-19.7-20.3C186.1 24.3 104.5 15.9 49.7 62.6c-62.8 53.6-66.1 149.8-9.9 207.9l193.5 199.8c12.5 12.9 32.8 12.9 45.3 0l193.5-199.8c56.3-58.1 53-154.3-9.8-207.9z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\"> Recommended by an oncologist or clinical geneticist<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aabfb4a elementor-widget elementor-widget-text-editor\" data-id=\"aabfb4a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4>\u00a0The course of the investigation<\/h4><p>The blood test at Villa Medicina is always preceded by a Genetic Counseling session, which takes place in person or online with the Istenhegyi G\u00e9ndiagnosztika specialist. The BRCA test can be performed if the Genetic Specialist recommends the test based on the consultation. In the event of a positive test, Istenhegyi G\u00e9ndiagnosztika provides another Genetic Consultation to interpret the results.<\/p><p class=\"translation-block\">The BRCA test is performed with a simple blood sample. During the laboratory analysis of the sample, special methods are used to map the BRCA1 and BRCA2 genes, as well as 23 other similar genes. After the results are available, our team of experts will help you interpret them, discuss further actions, and review possible preventive measures.<\/p><p>The test is preceded by a genetic counseling session, where the Geneticist discusses the patient's medical history, family history, and the expected benefits of the test. The test can be performed if the geneticist deems it justified.<\/p><h4><span style=\"color: inherit; text-align: var(--text-align);\"><br \/>Why can BRCA testing be life-saving?<\/span><\/h4><p>Early detection of hereditary breast and ovarian cancer significantly improves the chances of recovery. Regular check-ups and a conscious lifestyle can avoid late diagnosis and more serious consequences. Through genetic testing, not only the affected person, but also their family members, if their carrier status is clarified, can receive targeted, preventive care.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-573c820 elementor-mobile-align-center elementor-align-left elementor-widget elementor-widget-global elementor-global-2449 elementor-widget-button\" data-id=\"573c820\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-md\" href=\"https:\/\/villamedicina.salonic.hu\/showServices\/?placeId=3176&#038;specId=58906\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">APPOINTMENT<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Genetics no longer just tells us about our past \u2013 it can also shape our future health. We are increasingly learning that certain inherited gene mutations can significantly increase the risk of developing cancer. <\/p>","protected":false},"featured_media":4448,"template":"","categories":[],"tags":[],"class_list":["post-4434","szolgaltatas","type-szolgaltatas","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/villamedicina.hu\/en\/wp-json\/wp\/v2\/szolgaltatas\/4434","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/villamedicina.hu\/en\/wp-json\/wp\/v2\/szolgaltatas"}],"about":[{"href":"https:\/\/villamedicina.hu\/en\/wp-json\/wp\/v2\/types\/szolgaltatas"}],"version-history":[{"count":6,"href":"https:\/\/villamedicina.hu\/en\/wp-json\/wp\/v2\/szolgaltatas\/4434\/revisions"}],"predecessor-version":[{"id":5052,"href":"https:\/\/villamedicina.hu\/en\/wp-json\/wp\/v2\/szolgaltatas\/4434\/revisions\/5052"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/villamedicina.hu\/en\/wp-json\/wp\/v2\/media\/4448"}],"wp:attachment":[{"href":"https:\/\/villamedicina.hu\/en\/wp-json\/wp\/v2\/media?parent=4434"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/villamedicina.hu\/en\/wp-json\/wp\/v2\/categories?post=4434"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/villamedicina.hu\/en\/wp-json\/wp\/v2\/tags?post=4434"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}